2 chloro n 6 cyclopentyladenosine ccpa (Tocris)
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Structured Review
Tocris
2 chloro n 6 cyclopentyladenosine ccpa
2 Chloro N 6 Cyclopentyladenosine Ccpa, supplied by Tocris, used in various techniques. Bioz Stars score: 93/100, based on 78 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/chloro+n/2-Chloro-N6-cyclopentyladenosine/pmc13004594-32-4-10
Average 93 stars, based on 78 article reviews
2 Chloro N 6 Cyclopentyladenosine Ccpa, supplied by Tocris, used in various techniques. Bioz Stars score: 93/100, based on 78 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/chloro+n/2-Chloro-N6-cyclopentyladenosine/pmc13004594-32-4-10
Average 93 stars, based on 78 article reviews
2 chloro n 6 cyclopentyladenosine ccpa - by Bioz Stars,
2026-11
93/100 stars
Images
1) Product Images from "Specific GPCRs elicit unique extracellular vesicle miRNA array signatures"
Article Title: Specific GPCRs elicit unique extracellular vesicle miRNA array signatures
Journal: eLife
doi: 10.7554/eLife.107865
Figure Legend Snippet: ( A ) Dose-dependent cAMP accumulation after ADORA1 activation with agonist, 2-chloro- N 6 -cyclopentyladenosine (CCPA), or inhibition with antagonist 8-cyclopentyl-1,3-dipropylxanthine (DPCPX) (5 μM). ( B ) Dose-dependent IP1 accumulation after 2-pyridylethylamine dihydrochloride (PEA) stimulation of histamine receptor H1 (HRH1) and inhibition by cetirizine (1 μM). ( C ) Alkaline phosphatase (ALP) activity after stimulation of frizzled class receptor 4 (FZD4) by Wnt3a. ( D ) The ratio of phosphorylated ERK1/2 (pERK1/2) by total ERK 1/2 (tERK1/2) after stimulation of ACKR3 by SDF-1α. For all graphs, data are shown as mean ± SD, with n=3 independent repeats, each having duplicate determinants, ns = not significant, *p<0.05, **p<0.01, ***p<0.001 vs. vehicle control (VC). Statistical significances were determined by one-way or two-way ANOVA of receptors by agonists or antagonists and post hoc Tukey’s or Sidak’s testing for multiple comparisons.
Techniques Used: Activation Assay, Inhibition, Activity Assay, Control
Figure Legend Snippet: U2OS cells were incubated with VC or a selective agonist 2-chloro- N 6 -cyclopentyladenosine (CCPA) ( A ), 2-pyridylethylamine dihydrochloride (PEA) ( B ), Wnt3a ( C ), or SDF-1α ( D ) for ADORA1, HRH1, FZD4, and ACKR3, respectively. EVs were isolated, and the concentration was normalized as a percentage of the media control (MC). EV size distribution following agonist or VC treatment in ADORA1 ( E ), HRH1 ( F ), FZD4 ( G ), and ACKR3 ( H ). Data are shown as mean ± SEM, n=3. A t-test determined no significant differences in EV concentration or size distribution between the VC and agonist stimulation in all G protein-coupled receptors (GPCRs), p>0.05.
Techniques Used: Incubation, Isolation, Concentration Assay, Control
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